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Inventi Impact: Pharmacokinetics & Pharmacodynamics

Articles

  • Inventi:pkd/27056/18
    Pharmacokinetic Comparisons of Typical Constituents in Curcumae Rhizoma and Vinegar-\nProcessed Curcumae Rhizoma after Oral Administration to Rats
    01-Jan-1970 Research 2018 : October - December
    Wei Gu, Jin-ci Li, De Ji, Lin Li, Ji Zhang, Zi-hao Pan, Jun-jie Yang, Tu-lin Lu, Chun-qin Mao

    The Raw Curcumae Rhizoma (R-CR), included in the Chinese Pharmacopoeia Edition 2015, is a well-known Chinese herbal\nmedicine. However, the vinegar-processed Curcumae Rhizoma (V-CR) is used more widely than R-CR. The pharmacokinetics\ncomparison of R-CR and V-CR after oral administration to rats is poorly understood. A novel method, rapid resolution liquid\nchromatography-tandem mass spectrometry (RRLC-MS) coupled with a sensitive, specific, and convenient microdialysis sampling\nmethod, free fromendogenous interference was developed in this research.The extracts of R-CR andV-CRwere administered orally\nto each group of rats.The blood and liver microdialysis probes were positioned within the jugular vein toward the right atrium and\nthe median lobe near the center of the liver, respectively. Then, a double-peak phenomenon was observed in the concentrationtime\ncurves of curdione in R-CR group, while it was not observed in V-CR group. The liver-to-blood distribution ratio of curdione\nin V-CR group increased significantly (

    How to Cite this Article
    Wei Gu, Jin-ci Li, De Ji, et al.,\nâ??Pharmacokinetic Comparisons of Typical Constituents in\nCurcumae Rhizoma and Vinegar-Processed Curcumae Rhizoma\nafter Oral Administration to Rats,â? Evidence-Based\nComplementary and Alternative Medicine, vol. 2018, Article ID\n6809497, 11 pages, 2018. https://\ndoi.org/10.1155/2018/6809497, https://creativecommons.org/\nlicenses/by/4.0/.
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