Biologicals are important ocular drugs that are be delivered using monthly and bimonthly\nintravitreal injections to treat retinal diseases, such as age-related macular degeneration. Long acting\ndelivery systems are needed for prolongation of their dosing interval. Intravitreal biologicals are\neliminated from the eye via the aqueous humor outflow. Thus, the anterior and posterior segments are\nexposed to the drug. We utilized a kinetic simulation model to estimate protein drug concentrations\nin the vitreous and aqueous humor after bolus injection and controlled release administration to the\nvitreous. The simulations predicted accurately the experimental levels of 5 biologicals in the vitreous\nand aqueous humor. The good match between the simulations and experimental data demonstrated\nalmost complete anterior segment bioavailability, and major dose sparing with ocular controlled\nrelease systems. Overall, the model is a useful tool in the design of intraocular delivery of biologicals
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