(1) Background: Rhubarb anthraquinones-a class of components with neuroprotective\nFunction-can be used to alleviate cerebral ischemia reperfusion injury. (2) Methods: The three\npharmacodynamic indicators are neurological function score, brain water content, and cerebral\ninfarction area; UPLC-MS/MS was used in pharmacokinetic studies to detect plasma concentrations\nat different time points, and DAS software was used to calculate pharmacokinetic parameters in\na noncompartmental model. (3) Results: The results showed that the pharmacodynamics and\npharmacokinetics of one of the five anthraquinone aglycones could be modified by the other four\nanthraquinones, and the degree of interaction between different anthraquinones was different.\nThe chrysophanol group showed the greatest reduction in pharmacodynamic indicators comparing\nwith other four groups where the rats were administered one of the five anthraquinones, and there\nwas no significant difference between the nimodipine group. While the Aloe-emodin + Physcion\ngroup showed the most obvious anti-ischemic effect among the groups where the subjects were\nadministered two of the five anthraquinones simultaneously. Emodin, rhein, chrysophanol, and\nphyscion all increase plasma exposure levels of aloe-emodin, while aloe-emodin lower their plasma\nexposure levels. (4) Conclusions: This experiment provides a certain preclinical basis for the study\nof anthraquinone aglycones against cerebral ischemia and a theoretical basis for the study of the\nmechanism of interaction between anthraquinones.
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