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Inventi Impact: Pharmacokinetics & Pharmacodynamics

Articles

  • Inventi:pkd/31446/20
    Comparative Study on Pharmacokinetics of Four Active Compounds in Rat Plasma After Oral Administration of Raw and Wine Processed Chuanxiong Rhizoma
    Research 2020 : April - June
    Yan Ning, Ke Pei, Gang Cao, Hao Cai, Xiao Liu, Lilong Cao, Shuosheng Zhang, Baochang Cai

    In Chinese medicine, the effect of promoting blood circulation and removing stasis could\nbe enhanced after Chuanxiong Rhizoma is processed by wine. However, the relevant mechanism\nremains unclear. In this manuscript, a rapid and sensitive quantification method employing\nultrahigh performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) was\nestablished and validated to simultaneously determine butylidenephthalide, ligustilide, senkyunolide\nA and ferulic acid in rat plasma after oral administration of raw Chuanxiong Rhizoma (RCR) and\nwine-processed Chuanxiong Rhizoma (WCR) respectively. All analytes were extracted from plasma\nby proteins precipitation with methanol������

    How to Cite this Article
    Attribution/ CC Compliant Citation: Ning, Yan, et al. \"Comparative Study on Pharmacokinetics of Four Active Compounds in\nRat Plasma after Oral Administration of Raw and Wine Processed Chuanxiong Rhizoma.\" Molecules 25.1 (2020): 93.\nhttps://doi:10.3390/molecules25010093\nhttp://creativecommons.org/licenses/by/4.0/\n\nSome formatting elements, header, footer, logos, dates and pagination were modified while adapting this article.
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