This study optimized the preparation of electrosprayed microspheres containing leuprolide\nand developed an in vitroâ??in vivo correlation (IVIVC) model that enables mutual prediction between\nin vitro and in vivo dissolution. The pharmacokinetic (PK) and pharmacodynamic (PD) study\nof leuprolide was carried out in normal rats after subcutaneous administration of electrosprayed\nmicrospheres. The parameters of the IVIVC model were estimated by fitting the PK profile of Lucrin\ndepot® to the release compartment of the IVIVC model, thus the in vivo dissolution was predicted\nfrom the in vitro dissolution. From this correlation, the PK profile of leuprolide was predicted from the\nresults of in vivo dissolution. The IVIVC model was validated by estimating percent prediction error\n(%PE) values. Among prepared microspheres, an optimal formulation was selected using the IVIVC\nmodel......................
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