Griseofulvin (GF) is antifungal drug having poorly water solubility. Solubility is the main constraint for oral bioavailability of drug. An attempt has been made to increase the solubility of this model drug by formulating solid dispersion (SD) using solvent evaporation method of solid dispersion (SD) for that purpose different concentration of Poloxamer 188 (PXM 188) and poloxamer 407 is used as polymer and then formulating SDs tablets. Tablet formulations were prepared by direct compression technique using 32 full factorial designs for optimization of process variable. The dichloromethane is used as solvent for preparation of SDs. The SDs were evaluated for XRD, solubility, in vitro dissolution profiles, and dissolution efficiency, and developed tablet formulations were evaluated for various pharmaceutical characteristics viz. hardness, % friability, weight variation, drug content, in vitro dissolution profiles, and dissolution efficiency. Among different formulations of SDs, SD containing drug to polymer ratio 1 : 3 (drug to poloxamer 188 ratio) and concentration of poloxamer 407 is 100 mg gives best dissolution profile and solubility. A formulation containing drug to poloxamer 188 ratios 1:3 and poloxamer 407 conc. 100 mg gives best solubility and dissolution profiles compared with other formulations. Results showed that poloxamer188 and poloxamer 407 is a promising polymer for enhancing the solubility and dissolution of Griseofulvin.
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