The objective of the present paper was to determine the influence of fructooligosaccharide (FOS) on the pharmacokinetics of\r\nisoflavones in healthy postmenopausal women. The study was a fixed-sequence, two-phase, crossover study. Twelve subjects\r\nreceived a single oral dose of 300mL of a soy beverage. Blood samples were collected before the dose and at 0.5, 1, 2, 4, 6, 8, 10, 12,\r\n24, and 32 h after the administration of the soy beverage. After a washout period of at least 1 week, subjects were assigned to receive\r\noral doses of FOS, 5 g each time, twice a day (after breakfast and dinner) for 14 days, followed by a single oral dose of the same\r\nsoy beverage on the next day. Blood samples were then collected at the same time points mentioned previously. Plasma isoflavone\r\nconcentrations were determined by HPLC. Continuous oral administrations of FOS followed by a single oral administration of\r\nsoy beverage caused significant increases in Cmax, AUC0ââ?¬â??32, and AUC0ââ?¬â??8 of genistein and AUC0ââ?¬â??32 of daidzein, comparing to those\r\nobtained following a single oral dose of soy beverage alone. Other pharmacokinetic parameters (Tmax and t1/2 of both aglycones\r\nand AUC0ââ?¬â??8 of daidzein) between both regimens were not significantly different.
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