Plumericin, an iridoid lactone, was isolated with relatively high yield from Momordica charantia vine using the supercritical fluid\nextraction (SFE) and the separation box (Sepbox) comprising dual combination of high-performance liquid chromatography\nand solid phase extraction. This compound showed antibacterial activity against Enterococcus faecalis and Bacillus subtilis with\nminimum inhibitory concentration (MIC) values better than cloxacillin. Plumericin potently inhibited proliferation of two\nleukemic cancer cell lines: they were acute and chronic leukemic cancer cell lines, NB4 and K562, with the effective doses (ED50)\nof 4.35 �± 0.21 and 5.58 �± 0.35 ????g/mL, respectively. In addition, the mechanism of growth inhibition in both cell lines was induced\nby apoptosis, together with G2/M arrest in K562 cells.
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