Inflammation is one of the ten leading causes of mortality throughout the globe. Chronic inflammation contributes to the occurrence of many diseases which include heart disease, cancer, chronic lower respiratory disease, stroke, Alzheimer’s disease, diabetes and nephritis. The preference for herbal drugs is now a day is increasing. These drugs produce negligible side effects and enhance its vigor and strength. Guggul have been found useful in curing many diseases like rheumatism, arthritis, hyper-lipidemia, obesity, inflammation, atherosclerosis, wrinkles and acne. In the present study, we attempted to evaluate in-vitro anti-inflammatory activity of some Guggul containing polyherbal formulations using membrane stabilization assay. All the Guggul containing ayurvedic formulations significantly inhibited the hyposaline induced RBC hemolysis. Thus, it could be concluded that Aditya pak Guggul, Rasnadi Guggul, Tyayodashang Guggul, Punarnava Guggul, Saptavishanti Guggul, Amruta Guggul and Kishor Guggul possess significant membrane-stabilizing properties and hence anti-inflammatory activity. Furthermore, it may be concluded that these formulations through their membrane-stabilizing properties interfere with the early phase of inflammatory mediator release, particularly by mediating the release of phospholipase A2 that triggers the formation of such inflammatory mediators.
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