The peach tree, Prunus persica (L.) Batsch, is widely cultivated in China, and its flowers have been used for centuries in traditional\nChinese medicine to treat gut motility disorders. But few studies have explored the pharmacological effect of Prunus persica (L.)\nBatsch flowers on gastrointestinal motility. In this study, the activities of different extracts fromPrunus persica (L.) Batsch flowers on\nthe smoothmuscle contractionswere evaluated using isolated colonmodel, and the ethyl acetate extract (EAE) showed the strongest\neffects in vitro. EAE (10?8ââ?¬â??10?5 g/mL) caused a concentration-dependent stimulatory effect in rat colonic tissue. Additionally,\nketotifen (100 ????M), cimetidine (10 ????M), and pyrilamine (1 ????M) produced a significant inhibition of contractions caused by EAE.\nFurthermore, immunofluorescence and toluidine blue staining revealed increased numbers of mast cells in the EAE group, and\nEAE increased histamine release from the colonic tissues. These data indicate that EAE has significant prokinetic activity and acts\nby a mechanism that mainly involves mast cell degranulation. Our study provides a pharmacological basis for the use of an extract\nof Prunus persica (L.) Batsch flowers in the treatment of gut motility disorders
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