Cordyceps (CS) is a traditional Chinese herb with\nvarious biological effects that include immune modulation.\nCBG-CS-2 is a strain, Paecilomyces hepiali, of the Cordyceps\nspp. The anti-inflammatory effects of CBG-CS-2 were investigated.\nThe water-soluble fraction of CBG-CS-2 has high\nanti-inflammatory activity in LPS-induced Raw264.7 macrophages.\nWe tested the role of CBG-CS-2 on the antiinflammation\ncascade in LPS-stimulated Raw264.7 cells.\nCBG-CS-2 significantly decreased NO production, iNOS expression,\nand pro-inflammatory cytokine secretion in a dosedependent\nmanner. To investigate the mechanism by which\nCBG-CS-2 inhibits NO, iNOS, and pro-inflammatory cytokines,\nwe examined the activities of NF-?B and AP-1 in LPSactivated\nmacrophages. The results demonstrate that CBGCS-\n2 suppresses the production and expression of NO, iNOS,\nand pro-inflammatory cytokines in LPS-activated macrophages\nvia inhibition of NF-?B and AP-1, which may play\nan important role in inflammation. These findings suggest that\nCBG-CS-2 has modulatory effects on the inflammatory system\nin macrophages, and that it can serve as a useful antiinflammatory\ndietary supplement or drug.
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