Abstract: Sixteen compounds were isolated from the aerial parts of Sarcosperma\naffinis Gagnep. including (E)-phytol (1), heptadecan-1-ol (2), lupeol (3), oleanolic\nacid (4), 3�²-hexadecanoyloleanolic acid (5), pomolic acid (6), euscaphic acid (7),\nmyrianthic acid (8), (+)-pinoresinol (9), (+)-medioresinol (10), (+)-syringaresinol\n(11), quercetin-3-O-�²-D-galactopyranoside (12), epicatechin (13), bis-(2-ethylhexyl)\nphthalate (14), 3-prenyl-4-O-�²-D-glucopyranosyloxy-4-hydroxylbenzoic acid (15),\nicariside E5 (16). Their structures were elucidated by the combination of spectroscopy\nincluding 1D, 2D NMR, HR-ESI-MS and in comparison with the reported NMR data\nin the literature. Among those, compounds 4 and 6 showed potent antibacterial\nactivity against Mycobacterium smegmatis with MIC values of 5.48 and 2.65 �¼M, respectively.\nThe chemical composition and biological activity of constituents isolated\nfrom aerial parts of S. affinis was studied for the first time.
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