The present study was proposed to investigate the toxicological and prophylactic potential of ethanolic extracts of Rosa damascena\nand Nymphaea alba and their mixture in albino mice. For toxicity study, three different doses of plant extracts were orally\nadministrated to three groups of mice for 14 successive days. Blood biochemistry and histological examinations of liver and kidney\nrevealed that these extracts had no harmful effects up to 1000mg/kg. To determine the prophylactic effects of Rosa damascena,\nNymphaea alba, and their mixture, an infection model of Listeria monocytogenes was established in a pilot study. Establishment of\ninfection was confirmed by changes in haematological parameters and reisolation of Listeria monocytogenes from different tissues.\nResults showed that these extracts alone or in combination could restrict the growth of Listeria monocytogenes in different organs.\nNeutrophils were high in positive control group but remained in normal range in all treated groups. Listeria monocytogenes was\nrecovered in low numbers from animals treated with extract of single plant but was negligible in group treated with mixture of\nextract of plants. Platelets count was increased in treated groups as compared to control. Results confirmed that these extracts are\npotent source of antimicrobial compounds and that they have synergistic effect in combined form.
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