The present study was undertaken to evaluate adverse effects, if any, on the lipid and protein profiles in sheep fed with Bt.cotton plant material. A total of 32 Deccani sheep of one year old were randomly divided into 4 groups, consisting of 8 sheep in each group. Group 1: Basal diet (concentrate feed @ 300gm+green fodder @ 3kg / sheep /day), Group 2: Non-Bt cotton plant @1.5kg+ green fodder @1.5kg+ concentrate feed @ 300gm /sheep /day, Group 3: Bt cotton plants (50%) @1.5kg+ green fodder @1.5+ concentrate feed @ 300gm /sheep /day, Group 4: Bt cotton plants ad libitum + concentrate feed @ 300gm / sheep and all these groups were maintained for 90 days. The blood samples were drawn from jugular vein on 30th, 60th and 90th day for estimation of lipid and protein profiles. Pesticide analysis in Bt cotton plants was done by Gas Chromatography (GC), at the end of the experiment animals were slaughter and organs collected of histopathological study. The results showed no significant alteration were observed in the lipid and protein profile by feeding of Bt and Non Bt cotton plants and no pesticide residual were detected after spraying with pesticide on the Bt and Non Bt cotton plants. Further these results well supported by no evident change in the histopathological study. Therefore feeding of Bt cotton plant materials to animals did not exert any adverse toxic effect.
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