The pharmacological evaluation of the aqueous (AET) and ethanolic extracts (EET) of Adenanthera pavonina leaf was carried out for its anti-arthritic and antioxidant potential in adjuvant-induced arthritic rats. The study revealed the predominant anti-arthritic activity of ethanolic extract and it was concluded based upon the histopathological study and paw volume examination. The biological defence system constituting superoxide dismutase (SOD), catalase (CAT), glutathione peroxides (GPX), ascorbic acid and Vitamin E showed significant increase while the lipid peroxide content was found decreased to a large extent on both AET and EET treatment there by indicating the antioxidant property and indirectly to support anti- arthritic potential of the plant. Further it was concluded that the antioxidant property of the plant might be due to the presence of phytoconstituents like flavonoids, stigmasterol and triterpenoids in the ethanolic extract.
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