Angiogenesis plays a vital part in the pathogenesis and treatment of cardiovascular disease and has become one of the hotspots that\nare being discussed in the past decades. At present, the promising angiogenesis therapies are gene therapy and stem cell therapy.\nBesides, a series of studies have shown that the ultrasound targeted microbubble destruction (UTMD) was a novel gene delivery\nsystem, due to its advantages of noninvasiveness, low immunogenicity and toxicity, repeatability and temporal and spatial target\nspecificity; UTMD has also been used for angiogenesis therapy of cardiovascular disease. In this review, we mainly discuss the\ncombination of UTMD and gene therapy or stem cell therapy which is applied in angiogenesis therapy in recent researches, and\noutline the future challenges and good prospects of these approaches
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