Coronary artery atherosclerosis is a chronic inflammatory disease. This study aimed to identify the key changes of\ngene expression between early and advanced carotid atherosclerotic plaque in human. Methods. Gene expression dataset GSE28829\nwas downloaded from Gene Expression Omnibus (GEO), including 16 advanced and 13 early stage atherosclerotic plaque samples\nfrom human carotid. Differentially expressed genes (DEGs) were analyzed. Results. 42,450 genes were obtained from the dataset.\nTop 100 up- and downregulated DEGs were listed. Functional enrichment analysis and Kyoto Encyclopedia of Genes and Genomes\n(KEGG) identification were performed.The result of functional and pathway enrichment analysis indicted that the immune system\nprocess played a critical role in the progression of carotid atherosclerotic plaque. Protein-protein interaction (PPI) networks\nwere performed either. Top 10 hub genes were identified from PPI network and top 6 modules were inferred. These genes were\nmainly involved in chemokine signaling pathway, cell cycle, B cell receptor signaling pathway, focal adhesion, and regulation of\nactin cytoskeleton. Conclusion. The present study indicated that analysis of DEGs would make a deeper understanding of the\nmolecular mechanisms of atherosclerosis development and they might be used as molecular targets and diagnostic biomarkers\nfor the treatment of atherosclerosis
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