­
­
­
­

Inventi Impact: Gene Medicines

Articles

  • Inventi:pgm/26059/18
    Combining Genetic Variants to Improve Risk Prediction for NAFLD and Its Progression to Cirrhosis:\nA Proof of Concept Study
    01-Jan-1970 Research 2018 : July - September
    Umberto Vespasiani-Gentilucci, Chiara Dellâ??Unto, Antonio De Vincentis, Andrea Baiocchini, Marco Delle Monache, Roberto Cecere, Adriano Maria Pellicelli, Valerio Giannelli, Simone Carotti, Giovanni Galati, Paolo Gallo, Francesco Valentini, Franca Del Nonno, Davide Rosati, Sergio Morini, Raffaele Antonelli-Incalzi, Antonio Picardi

    Background&Aims;. Identifying NAFLD patients at risk of progression is crucial to orient medical care and resources.We aimed to\nverify if the effects determined by different single nucleotide polymorphisms (SNPs) could add up tomultiply the risk ofNAFLDand\nNASH-cirrhosis. Methods.Three study populations, that is, patients diagnosed with NASH-cirrhosis or with noncirrhotic NAFLD\nand healthy controls, were enrolled. PNPLA3 rs738409, TM6SF2 rs58542926, KLF6 rs3750861, SOD2 rs4880, and LPIN1 rs13412852\nwere genotyped. Results. One hundred and seven NASH-cirrhotics, 93 noncirrhotic NAFLD, and 90 controls were enrolled. At\nleast one difference in allele frequency between groups was significant, or nearly significant, for the PNPLA3, TM6SF2, and KLF6\nvariants (

    How to Cite this Article
    Umberto Vespasiani-Gentilucci, Chiara\nDell'Unto, Antonio De Vincentis, et al., â??Combining Genetic Variants\nto Improve Risk Prediction for NAFLD and Its Progression to\nCirrhosis: A Proof of Concept Study,â? Canadian Journal of\nGastroenterology and Hepatology, vol. 2018, Article ID 7564835, 9\npages, 2018. https://doi.org/10.1155/2018/7564835, https://\ncreativecommons.org/licenses/by/4.0/.
    Download Full Text