Hydroxide [Ag(OH)L] (L = IVL, VL, VIL, VIIL), oxide [{AgL}2}(micro-O)] (L = IL, IIL, IIIL,\nVL, VIL) or chloride [AgIIL]Cl, [Ag(VIL)2]Cl complexes were obtained from reactions of mono- or\nbicamphorimine derivatives with Ag(OAc) or AgCl. The new complexes were characterized by\nspectroscopic (NMR, FTIR) and elemental analysis. X-ray photoelectron spectroscopy (XPS), ESI\nmass spectra and conductivity measurements were undertaken to corroborate formulations. The\nantimicrobial activity of complexes and some ligands were evaluated towards Candida albicans\nand Candida glabrata, and strains of the bacterial species Escherichia coli, Burkholderia contaminans,\nPseudomonas aeruginosa and Staphylococcus aureus based on the Minimum Inhibitory Concentrations\n(MIC). Complexes displayed very high activity against the Candida species studied with the lowest\nMIC values (3.9 microg/mL) being observed for complexes 9 and 10A against C. albicans. A significant\nfeature of these redesigned complexes is their ability to sensitize C. albicans, a trait that was not\nfound for the previously investigated [Ag(NO3)L] complexes. The MIC values of the complexes\ntowards bacteria were in the range of those of [Ag(NO3)L] and well above those of the precursors\nAg(OAc) or AgCl. The activity of the complexes towards normal fibroblasts V79 was evaluated by\nthe MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide) assay. Results showed that\nthe complexes have a significant cytotoxicity.
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