Effective antimicrobials are crucial for managing Staphylococcus aureus implant-associated\nbone infections (IABIs), particularly for infections due to rifampin-resistant S. aureus (RRSA). Failure\nto remove the implant results in persistent infection; thus, prolonged suppressive antibiotic\ntherapy may be a reasonable alternative. However, a high incidence of adverse events can\nnecessitate the discontinuation of therapy. In this scenario, commercial Staphylococcal bacteriophage\nSb-1 combined with antibiotics is an option, showing a promising synergistic activity to facilitate\nthe treatment of biofilm infections. Therefore, we evaluated the efficacy of the inhibitory activity\nof five antibiotics (doxycycline, levofloxacin, clindamycin, linezolid, and rifampin) alone or\ncombined with phage.....................
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