Phytol is a diterpene alcohol and can be found as a product of the metabolism of\nchlorophyll in plants. This compound has been explored as a potential antimicrobial agent, but it is\ninsoluble in water. In this study, we describe a novel approach for an interesting anticandidal drug\ndelivery system containing phytol. Different formulations of phytol-loaded solid lipid nanoparticles\n(SLN) were designed and tested using a natural lipid, 1,3-distearyl-2-oleyl-glycerol (TG1). Different\ncompositions were considered to obtain three formulations with 1:10, 1:5, and 1:3 w/w phytol/TG1\nratios. All the formulations were prepared by emulsification solvent evaporation method and had\ntheir physicochemical properties assessed. The biocompatibility assay was performed in the HEK-293\ncell line and the antifungal efficacy was demonstrated in different strains of Candida ssp., including\ndifferent clinical isolates......................................
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