Mucus in fishes plays a major role in protecting against external bacterial, parasitic and fungal infestation. Hence, the\r\nmucus acts as a significant defence barrier and plays a key role in innate immunity. The research emphasizes on the\r\nantimicrobial property and haemolytic efficacy of the epidermal mucus of the striped dwarf catfish, Mystus vittatus collected\r\nfrom the Vellar estuary, Parangipettai. The collected mucus sample was then lyophilized and extracts namely, aqueous, acidic\r\nand organic were prepared and analysed for its antimicrobial activity against selected human and fish pathogens. The hemolytic\r\nefficacy of epidermal mucus was performed. The results of the present investigations reported that mucus of Mystus vittatus\r\npossess remarkable antimicrobial activity. The crude and organic extracts exhibited good haemolytic activity. Hence, the mucus\r\nextract could be a novel candidate against emerging disease scenario in the future. Also, this study will serve as the base for\r\nfurther in-depth investigations and structural elucidation.
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