There is increase in the number of cases of diabetics day by day. Inhibitors of protein tyrosine phosphatase can desirable to achieve antidiabetic activity. Bromophenols are the compounds reported as the inhibitors of protein tyrosine phosphatase 1B. Hence a series of bromophenol derivatives compounds were taken from Dayong Shi et al., to inhibit protein tyrosine phosphate 1B for antidiabetic activity. In the present research 28 molecules were studied for the docking study. Orientation pattern, best poses, hydrogen bond interaction were studied for getting the possible significant molecule. The result showed that 10 molecules have shown significant score in docking. Out of that the molecule 2a has shown best score. Docking study was carried out with the software SYBYL X2.0. Computational approach was employed so as to achieve the better chemical entity that can inhibit the protein tyrosine phosphatase 1B.
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