Inosine 5'-monophosphate dehydrogenase (IMPDH) is one of the crucial enzymes in the de novo biosynthesis of guanosine\nnucleotides. It has served as an attractive target in immunosuppressive, anticancer, antiviral, and antiparasitic therapeutic strategies.\nIn this study, pharmacophoremapping andmolecular docking approaches were employed to discover novelHomo sapiens IMPDH\n(hIMPDH) inhibitors. The G�¨uner-Henry (GH) scoring method was used to evaluate the quality of generated pharmacophore\nhypotheses. One of the generated pharmacophore hypotheses was found to possess a GH score of 0.67. Ten potential compounds\nwere selected from the ZINC database using a pharmacophore mapping approach and docked into the IMPDH active site.We find\ntwo hits (i.e., ZINC02090792 and ZINC00048033) that match well the optimal pharmacophore features used in this investigation,\nand it is found that they forminteractions with key residues of IMPDH.We propose that these two hits are lead compounds for the\ndevelopment of novel hIMPDH inhibitors
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