Six novel imidazoline derivatives were synthesized and tested in antifungal assays.\nOne of the compounds, N-cyclohexyl-2-imino-3-(4-nitrophenyl)imidazolidine-1-carboxamide\nshowed moderate activity against several clinical strains of Candida albicans. Its structure\nwas solved by X-ray crystallography and its mode of action was deduced using molecular\nmodelling. It was found to be similar to that of fluconazole. The potential for further\noptimization including SAR of the compound is briefly discussed.
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