Acetyl-coenzyme A carboxylases (ACCs) play critical roles in the regulation of\nfatty acid metabolism and have been targeted for the development of drugs against obesity,\ndiabetes and other metabolic diseases. Two series of compounds possessing quinoline\nmoieties were designed, synthesized and evaluated for their potential to inhibit acetyl-CoA\ncarboxylases. Most compounds showed moderate to good ACC inhibitory activities and\ncompound 7a possessed the most potent biological activities against ACC1 and ACC2,\nwith IC50 values of 189 nM and 172 nM, respectively, comparable to the positive control.\nDocking simulation was performed to position compound 7a into the active site of ACC to\ndetermine a probable binding model.
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