Cyclooxygenase come into sight as one of the important target for noval anti-inflammatory agents. The present study aims to reveal characteristic binding mechanism of SC-75416 and SD-8381. The SC-75416 interacts with cox-2 in a stereochemical way in which existence of enantiomerism plays crucial role. The orientation SC-75416 in cox-2 binding pocket was governed by different enantiomeric forms whereas no such binding mechanism was reported for SD-8381.
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