Biperiden is a drug used in Parkinson disease treatment and it serves also as an antiseizures compound in organophosphates\npoisoning. It acts as antagonist of muscarinic receptor activated by acetylcholine while the enzyme acetylcholinesterase (AChE)\ncleaves acetylcholine in synaptic junction into choline and acetic acid. This enzyme is inhibited by various compounds; however\nthere has not been proposed evidence about interaction with biperiden molecule. We investigated this interaction using standard\nEllman�s assay and experimental findings were critically completed with an in silico prediction by SwissDock docking software.\nUncompetitivemechanismof actionwas revealed fromDixon plot and inhibition constant (
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