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Inventi Impact: Molecular Modeling

Articles

  • Inventi:pmm/31985/20
    Investigation of a Direct Interaction Between miR4749 and the Tumor Suppressor p53 by Fluorescence, FRET and Molecular Modeling
    Research 2020 : July - September
    Anna Rita Bizzarri, Salvatore Cannistraro

    Abstract: The interactions between the DNA binding domain (DBD) of the tumor suppressor p53 and\nmiR4749, characterized by a high sequence similarity with the DNA Response Element (RE) of p53,\nwas investigated by fluorescence spectroscopy combined with computational modeling and docking.\nFluorescence quenching experiments witnessed the formation of a specific complex between DBD\nand miR4749 with an affnity of about 105 M. Förster Resonance Energy Transfer (FRET) allowed\nus to measure a distance of 3.9................

    How to Cite this Article
    Attribution/ CC Compliant Citation: Bizzarri, Anna Rita, and Salvatore Cannistraro. \"Investigation of a Direct Interaction between miR4749 and the Tumor Suppressor p53 by Fluorescence, FRET and Molecular Modeling.\" Biomolecules 10.2 (2020): 346.\nhttps://doi.org/10.3390/biom10020346\nhttp://creativecommons.org/licenses/by/4.0/\nSome formatting elements, header, footer, logos, dates and pagination were modified while adapting this article.
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