The present investigation focuses on the discovery of novel PDE4 inhibitor for Glomerulonephritis Asthma, COPD a Bipolar depression autoimmune encephalomyelitis. In this context, we have identified novel lead zinc_8442272 using target search option in the zinc database. The docking analysis revealed that ligand zinc_8442272 interacts with PDE4 enzyme through hydrogen bonding, arene-arene, polar interactions and nonbonding interactions. The analysis conclude that para substituted methoxy group, benzene ring on both terminal, sulphonamide substituent are essential for PDE4 inhibition. Further substitution of any hydrogen bond acceptor on benzene ring over second terminal may be beneficial enhancing PDE4 inhibition.
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