The aim of presented research is to develop a simple and quick method of spectrophotometric
detection for the determination of doxorubicin hydrochloride in blood and plasma. Anthracycline
antibiotics are among the most effective antineoplastic agents. However, despite their high efficacy
in the treatment of various types of cancer, their administration is limited primarily because they
exhibit myocardial toxicity. This may be a limiting factor in the dosage of medications; nevertheless,
drugs exhibiting this mechanism of action constitute a very important group of chemotherapeutics.
One of the more widely studied antibiotics from the anthracycline group is doxorubicin. It exhibits
the highest antineoplastic activity from among a number of derivative compounds. Because of the
adverse effects of doxorubicin, especially cardiotoxicity, it is important to maintain control of its
concentration in body fluids. The method in the study consists of extraction doxorubicin from the
plasma or blood and measurements of the absorbance of light in the visible light range in a DOX
solution with respect to a reference sample. The research used blood and plasma samples spiked with
doxorubicin to give concentrations................
� Copyright©2013. Inventi Journals Pvt.Ltd. All Right Reserved.