In present investigation attempt was made to improve dissolution profile of pioglitazone HCl using xanthan gum (XG) and modified xanthan gum (MXG) as carriers by solid dispersion technique. The XG and MXG were characterized for viscosity, swelling index and water retention capacity. Solid dispersion was prepared by kneading method using XG and MXG in ratio of 1:1, 1:2 and 1:3 respectively. The solubility data showed that solubility of pioglitazone HCl was increased with XG and found high with MXG. The FTIR, DSC and XRD studies were done. The XRD study showed crystalline nature of pure drug which was converted into amorphous form in solid dispersion. The optimized formulations X4 and M4 showed higher in-vitro drug release 85.37% and 99.21% respectively in 120 min and higher absorption against pure pioglitazone HCl. It was concluded that MXG could be a novel approach in enhancing solubility of drug.
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