The aim of this study was to describe the mechanical and sorption features of homogeneous and composite membranes which\nconsist of microcrystalline chitosan (MCCh) and fibrin (Fb) in various proportions as well as the in vitro kinetics of platelet-derived\ngrowth factor-BB (PDGF-BB) released fromten types of membranes in the presence or absence of amoxicillin (Am).Thefilms were\ncharacterized by Fourier transform infrared (FTIR) spectroscopy, mechanical tests: breaking strength (Bs) and elongation at break\n(Eb), as well as SEMimages, and swelling study.The influence of the formof samples (dry or wet) on Young�s modulus (E) was also\nexamined.The homogeneous MCCh (M1) and composite M3 and M4 (MCCh : Fb = 2 : 1 and 1 : 1) membranes were characterized\nby good sorption properties and higher mechanical strength, when compared with Fb (M2) membrane. Connecting MCCh with\nFb decreases release of PDGF-BB and increases release of Am. The most efficient release of PDGF-BB was observed in the case of\nM4 (the optimum MCCh : Fb ratio was 1 : 1) membrane. It was found that the degree of PDGF-BB release from the membrane is\ninfluenced by the physicochemical and mechanical characteristics of the films and by its affinity to growth factor PDGF-BB.
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