The physical properties of pharmaceutical powders/granules are very important in the development of\noral solid dosage forms. The aim of this paper was, in a first stage, to carry out an evaluation of the flow properties\n(angle of repose, flow time, compaction capacity, compressibility index, Carr index and Hausner ratio) of\ntechnological or primary excipients of tablets (microcrystalline cellulose and dibasic calcium phosphate dihydrate)\nwhich behave differently during compaction, either pure and in binary mixtures, whose composition varied between\n20% (w/w) and 80% (w/w) at intervals of 20% (w/w). In a second stage, using an instrumented eccentric tableting\nmachine, energies and exerted forces during compaction of these materials were measured and the compressibility\ncurves were registered. In addition, plasticity index and lubrication coefficient were calculated and weight\nuniformity, thickness, hardness and tensile strength of the manufactured tablets were also evaluated. The obtained\nresults demonstrated that the binary mixtures and the pure excipients showed similar flow properties. On the other\nhand, the obtained tablets with the plastic excipient had lower values of exerted force by the upper punch and\napparent net energy, and higher values of plasticity index and time periods of the force/time compression profiles.
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