Cellulose is an important pharmaceutical excipient. This study aimed to produce cellulose from the fiber of Luffa cylindrica as an\neffective binder in the formulation of acetaminophen tablets. This study was divided into three phases, namely, (I) preparation of\ncellulose fromLuffa cylindrica, (II) determination of the powder properties of the LC-cellulose, and (III) production and evaluation\nof acetaminophen of the tablets produced using LC-cellulose as binder.The percentage yield of LC-cellulose was 61%. The values\nof the powder properties of LC-cellulose produced show fair and passable flow properties and are within the specifications of a\npowdered pharmaceutical excipient. The mean tablet hardness and disintegration time of the LC-cellulose tablets have a significant\ndifference in the mean tablet hardness and disintegration time of the tablets without binder; thus the cellulose produced improved\nthe suitability of acetaminophen in the dry compression process. However, the tablet properties of the tablets produced using LCcellulose\nas binder do not conformto the specifications of the US pharmacopeia; thus the study of additional methods and excipients\nis recommended.
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