The demand for mouth dissolving tablets has been growing, during the last decade, especially for geriatric and paediatric patients who have swallowing difficulties. Superdisintegrants are responsible to disintegrate the tablet into small particles, which in turn increases the surface area for dissolution, thereby increasing the dissolution rate of poorly soluble drugs. Though a wide range of superdisintegrants are available, there is a continued need to develop new, safe superdisintegrants for fast dissolving tablets. In the present investigation, starch butyrate, a new starch based superdisintegrant was prepared and evaluated for its application in the design of a poorly soluble drug, ketoprofen by employing 23 factorial design.
Loading....