The present work was aimed to develop novel oral antihypertensive sustained release intestinal mucoadhesive tablets of valsartan using novel natural polymer isolated from Coccinia grandis and chitosan. The tablets were prepared by using different concentration of polymer of Coccinia grandis and chitosan by wet granulation method. For the study purpose, both of above polymer were selected as the model polymers. The purpose of present study was to evaluate Coccinia grandis and chitosan for mucoadhesive properties and to formulate intestinal mucoadhesive tablet of valsartan (model drug) to keep the dosage form in the small intestinal region for about 24 hours for the treatment of hypertension and heart failure. Characterization of drug and compatibility among the formulation components was assessed by FTIR analysis. Two different methods were developed to isolate polymer from the fruits of Coccinia grandis. Compressed tablets were evaluated for various parameters like weight variation, drug content, hardness, friability, in-vitro drug release. Prepared core tablets were press coated with cellulose acetate phthalate (CAP) in different ratios. After optimizing coating ratio, prepared tablets were evaluated for hardness, friability, weight variation, thickness, in-vitro dissolution study, ex-vivo residence time, ex-vivo mucoadhesive force and drug content, swelling behaviour. A 32 randomized full factorial design was used. Amount of novel polymer (X1) and amount of chitosan (X2) were selected as independent variables. The ex-vivo residence time of tablet and cumulative percentage drug release at 24 hours (Q24), were selected as dependent variables. The kinetic data obtained from in-vitro drug release studies of optimized batch indicates that the drug release data not only showed good fit into the higuchi equation (R2 = 0.992) but also partially fitted in zero order equation (R2 = 0.974). The developed optimized batch containing 7.5% w/v novel natural polymer and 2.5% w/v chitosan was selected as an optimized batch as it has shown 97.64% drug release and ex-vivo residence time for about 24 h.
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