The objective of the current research article is to provide a comprehensive review of excipients\nimpact on the stability of the drug product and their implications during the product development.\nRecent developments in the understanding of the degradation pathways further impact methodologies\nused in the pharmaceutical industry for potential stability assessment. The formation of\ndrug excipient adducts was very common based on the sensitive chemical moieties in the drugs\nand the excipients. The formation of the impurities was not limited to drug related impurities but\nthere were several possibilities of the drug-excipient adduct formations as well as excipient impurities\nreaction with Active Pharmaceutical Ingredients. Identification of drug degradation in\npresence of excipients/excipient impurities requires extensive knowledge and adequate analytical\ncharacterization data. Systematic literature review and understanding about the drug formulation\nprocess, give you a smooth platform in establishing the finished product in the drug market.\nThis paper discusses mechanistic basis of known drug-excipient interactions with case studies and\nprovides an overview of common underlying themes in solid, semisolid and parenteral dosage\nforms.
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