Chitin, the excellent biocompatible and biodegradable polymer, does not find much practical applications in the\npharmaceutical and biomedical fields owing to its insolubility in common solvents. This aspect has been discoursed by the\nsynthesis of mixed ester derivatives (acetyl and propionyl) of chitin. In the present investigation, the sustained release potential\nof the synthesized chitin co-(acetate/propionate) copolymers has been evaluated by formulating the matrix tablets of metformin\nhydrochloride (MFH) and comparing them with the marketed sustained release tablets (Glycomet�®-500 SR). IR investigations\nconfirmed the absence of drug polymer interactions in the developed formulations. Although, all the batches of formulated\ntablets showed somewhat sustained release of the drug, but the drug release profile of formulation F7 (containing AA70/PA30\nCAPC copolymer) was almost similar to that of the marketed formulation and both of them showed drug release up to 12 hours.\nThe drug release from the formulations F8 and F9 (containing AA80/PA20 and AA90/PA10 CAPC copolymers, respectively) was\nstill slower indicating their use at a lower concentration. Therefore, the outcomes of the present study indicates AA70/PA30,\nAA80/PA20 and AA90/PA10 CAPC copolymers as attractive matrix forming agents for sustained release tablets of MFH.
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