The successful topical therapy of onychomycosis depends on effective drug release and penetration into nail, which can be achieved\nby using an adequately developed delivery system. This study evaluated and compared effect of film-forming polymers Eudragit\nRL100, Eudragit RS100, and ethyl cellulose on naftifine hydrochloride release fromexperimental nail lacquer formulations. Quality\nof formulations was evaluated by determining drying time and water resistance. Interactions between active pharmaceutical\ningredient and excipients were investigated using microcalorimetry and FT-IR. Optimization of nail lacquer formulations was\nperformed by naftifine hydrochloride release testing. Release of naftifine hydrochloride increased with increasing concentration of\nEudragit RL100. Plasticizer triacetin affected the release of naftifine hydrochloride, when Eudragit RS100 polymer was used. Ethyl\ncellulose polymer was determined to be not applicable for naftifine hydrochloride nail lacquer formulations. Two compositions of\nnail lacquers were optimized and could be used in further development of transungual delivery systems.
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