The main challenges facing efforts to prevent the transmission of human immunodeficiency\nvirus (HIV) are the lack of access to sexual education services and sexual violence against young\nwomen and girls. Vaginal formulations for the prevention of sexually transmitted infections\nare currently gaining importance in drug development. Vaginal mucoadhesive tablets can be\ndeveloped by including natural polymers that have good binding capacity with mucosal tissues,\nsuch as chitosan or guar gum, semisynthetic polymers such as hydroxypropylmethyl cellulose,\nor synthetic polymers such as EudragitÃ?® RS. This paper assesses the potential of chitosan for the\ndevelopment of sustained-release vaginal tablets of Tenofovir and compares it with different polymers.\nThe parameters assessed were the permanence time of the bioadhesionââ?¬â?determined ex vivo using\nbovine vaginal mucosa as substrateââ?¬â?the drug release profiles from the formulation to the medium\n(simulated vaginal fluid), and swelling profiles in the same medium. Chitosan can be said to allow\nthe manufacture of tablets that remain adhered to the vaginal mucosa and release the drug in a\nsustained way, with low toxicity and moderate swelling that ensures the comfort of the patient and\nmay be useful for the prevention of sexual transmission of HIV.
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