The aim of the study was to investigate the effects of the loading factors, i.e., the initial\ndrug loading concentration and the ratio of the drug to carriers, on the in vitro pharmaceutical\nperformance of drug-loaded mesoporous systems. Ibuprofen (IBU) was used as a model drug, and\ntwo non-ordered mesoporous materials of commercial silica SyloidÃ?® 244FP (S244FP) and NeusilinÃ?®\nUS2 (NS2) were selected in the study. The IBU-loaded mesoporous samples were prepared by a\nsolvent immersion method with a rotary evaporation drying technique and characterized by polarized\nlight microscopy (PLM), Fourier transform infrared (FTIR) spectroscopy, X-ray powder diffraction\n(XRPD) and differential scanning calorimetry (DSC). Dissolution experiments were performed in\nsimulated gastric media at 37 ââ??¦C under non-sink conditions. The concentration of IBU in solution\nwas determined by HPLC. The study showed that the dissolution rate of IBU can be improved\nsignificantly using the mesoporous S224FP carriers due to the conversion of crystalline IBU into\nthe amorphous form. Both of the loading factors affected the IBU dissolution kinetics. Due to the\nmolecular interaction between the IBU and NS2 carriers, the loading factors had little effects on\nthe drug release kinetics with incomplete drug desorption recovery and insignificant dissolution\nenhancement. Care and extensive evaluation must therefore be taken when mesoporous materials\nare chosen as carrier delivery systems.
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