As coprocessed excipients (CPE) gain a lot of focus recently, this article compares three commercially available CPE of Avicel brand,\nnamely, CE 15, DG, and HFE 102. Comparison is based on measured physical properties of coprocessed mixtures, respectively,\nflow properties, pycnometric density, mean particle size, specific surface area, moisture content, hygroscopicity, solubility, pH\nleaching, electrostatic charge, SEMimages, and DSC. Tablets were made employing three pressure sets. Viscoelastic properties and\nejection force were assessed during compression, as well as pycnometric density, mass uniformity, height, tensile strength, friability,\ndisintegration, andwetting times.Avicel CE 15 is of mid-range flowproperties, contains mid-size and nonspherical particles, and has\nhigh hygroscopicity, growing negative charge, best lubricity, lowest tensile strength, and mid-long disintegration times. Avicel DG\npossesses the worst flow properties, small asymmetrical particles, lowest hygroscopicity, stable charge, intermediate lubricity, and\ntensile strength and exhibits fast disintegration of tablets. Finally, Avicel HFE 102 has the best flow properties, large symmetrical\nparticles, and middle hygroscopicity and its charge fluctuates throughout blending. It also exhibits inferior lubricity, the highest\ntensile strength, and slow disintegration of tablets. Generally, it is impossible to select the best CPE, as their different properties fit\nversatile needs of countless manufacturers and final products.
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