Taro Boloso-I (TB1), a newly improved Colocasia esculenta variety, is a potential source of starch with high yield. However, to\nimprove some limitations of the native starches (NS), such as flowability and compactibility, different physical and chemical starch\nmodifications have been employed. Acetylation is one of the chemical modifications which improves the flow and compaction of the\nNS, which are prerequisite during direct compression (DC) of tablets. Hence, in this study, TB1 starch was acetylated using acetic\nanhydride and evaluated as an ideal excipient for direct compression. Starch acetates (SA) with a degree of substitution (DS) of 0.072\n(SA1) and 0.695 (SA2) were produced and evaluated. FTIR spectra of the SAs were used to verify the acetylation of the NS. Powder\nflow evaluation parameters showed significant improvement in the flow properties of the NS following acetylation. In addition, the\nswelling power, solubility, and compactibility were also improved. Tensile strength (TS) of the tablets comprising SAs only, SA1\n(41.40) and SA2 (63.43 Kg/cm2), was significantly higher than tablets made of the NS (31.96) and Starch 1500® (15.12 Kg/cm2). The SAs\nalso showed lower sensitivity towards lubrication than the NS and Starch 1500® as lower lubricant sensitivity ratios were recorded. In\naddition, tablets comprising the SAs satisfactorily accommodated at least up to 50% w/w paracetamol-compared to 30 %w/w by Starch\n1500®-upon DC processing. The paracetamol tablets comprising SAs also complied with the United States Pharmacopeia specifications\nfor disintegration and dissolution studies. Therefore, taking all the facts into consideration, the SAs could be potential DC excipients in\ntablet formulations.
Loading....