This study tested 15 direct compaction grades to identify the contribution of different\ngrades of mannitol to the storage stability of the resulting tablets. After preparing the model\ntablets with different values of hardness, they were stored at 25 DegreeC, 75% relative humidity for\n1 week. Then, measurement of the tablet properties was conducted on both pre- and post-storage\ntablets. The tablet properties were tensile strength (TS), friability, and disintegration time (DT).\nThe experimental data were analyzed using a Kohonen self-organizing map (SOM). The SOM analysis\nsuccessfully classified the test grades into three distinct clusters having different changes in the\nbehavior of the tablet properties accompanying storage. Cluster 1 showed an obvious rise in DT\ninduced by storage, while cluster 3 showed a substantial change in mechanical strength of the tablet\nincluding a reduction in the TS and a rise in friability. Furthermore, the data were analyzed using\nan Elastic net regression technique to investigate the general relationships between the powder\nproperties of mannitol and the change behavior of the tablet properties. Consequently, we succeeded\nin identifying the crucial powder properties for the storage stability of the resulting tablets. This study\nprovides advanced technical knowledge to characterize the effect of different direct compaction\ngrades of mannitol on the storage stability of tablet properties.
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