Carbamazepine is used for anti convulsant and anti neuralgic effects. It is poorly soluble in water with erratic oral absorption and bioavailability less than 70%. More over carbamazepine has a narrow therapeutic range and shows bioavailability differences. In efforts to reduce the frequency of dosing required for chronic carbamazepine therapy and to decrease variability in plasma concentration, carbamazepine can be formulated in to controlled release systems In recent years, the natural hydrophilic polymer based matrix tablets as carrier for controlled release delivery has been widely and successfully used due to their ease of manufacturing, relatively low cost, favorable in vivo performance and versatility in controlling the release of drug with wide range of physicochemical properties. In the present study an effort was made to extract the Hibiscus rosa sinensis gum from the leaves of Hibiscus rosa sinensis and to evaluate it as controlled release polymer in the preparation controlled release matrix tablets of carbamazepine. The result of the present study demonstrated that the Hibiscus rosa sinensis gum obtained from the leaves of Hibiscus rosa sinensis is light green coloured powder which is amorphous in nature. Drug release from the prepared tablets was slowed over 24h and depended on the composition of Hibiscus rosa sinensis gum. Carbamazepine release was diffusion controlled and followed zero order kinetics. Non-fickian diffusion was the drug release mechanism from the prepared carbamazepine controlled release tablets. Therefore Hibiscus rosa sinensis gum is an efficient release retarding polymer for controlled release tablets.
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