The aim of this investigation was to develop novel multifunctional co-processed diluents for oral disintegrating tablets by melt granulation and wet granulation techniques. In case of wet granulation technique the co-processed diluents were formulated using micocrystalline cellulose and mannitol in the ratio 1:5.In case of melt granulation technique coprocessed diluents were formulated using PEG 4000 and PEG 6000, microcrystalline cellulose and mannitol were used as diluents, sodium starch glycolate as disintegrant . Magnesium stearate and talc were also incorporated as minor components in the diluent to improve tabletting properties. Donepezil HCl was used as poorly compressible model drug for preparation of tablets. The developed co-processed diluents were studied for their influence on flow, strength of the tablet and dissolution characteristics of Donepezil HCl from direct compressible tablets. Optimized co-processed formulation containing polyethylene glycol 6000 and mannitol was found to be more acceptable to formulate Donepezil HCl tablets. The preformulation parameters like flow property and the performance parameters were dependent on the method used for co-processing excipient. The co-processed excipient prepared with melt granulation technique imparted the desired qualities to the tablet.
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