Chitosan, a linear binary heteropolysaccharide, composed of β-1, 4-linked glucosamine (GlcN) with various degrees of N-acetylation of GlcN residues. It is a non-toxic, biocompatible and biodegradable natural polymer. Chitosan is prepared by alkaline N-deacetylation of chitin using concentrated sodium hydroxide (NaOH) solutions at high temperature for a long period of time. The degree of deacetylation (DD) and molecular weight (MW) are two fundamental parameters that can affect the properties and functionality of chitosan. Hydrophilic polymers are widely used in controlled release systems due to their favorable functionality. Enhancing the mobility of the polymer chains and diffusing of the drug out from such polymer matrices could be done by inclusion of different types of excipients at different concentrations. The present research paper highlights the attempt made to reveal the influence of the solubility of excipient on drug release from matrix systems with varying concentration of different grades of chitosan.
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