A new series of thiazole, pyrimidine and piperazine derivatives were tested for their in-vitro cytotoxicity activity against two cancer cell lines HeLa and HL60 and one normal cell line HEK293 by XTT assay method. Amongst the thiazole derivatives, one compound out of seven showed maximum activity (IC50 1.589 µM) against HL60 cell line. Amongst the pyrimidine derivatives, one compound out of five exhibited maximum activity (IC50 1.373 µM) against HeLa cell line. Amongst the piperazine derivatives, one compound out of four showed maximum activity (IC50 1.675 µM) against HeLa cell line. None of the above compounds exhibited cytotoxicity activity to the normal cells that is HEK293 cells (Human Kidney) in the compound concentration range of 5 nM to 100 µM.
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