Experimental animal models improve our understanding of technical problems in peritoneal dialysis PD, and such studies\ncontribute to solving crucial clinical problems. We established an acute and chronic PD model in non uremic and uremic rats.\nWe observed that kinetics of PD in rats change as the animals are aging, and this effect is due not only to an increasing peritoneal\nsurface area, but also to changes in the permeability of the peritoneum. Changes of the peritoneal permeability seen during chronic\nPD in rats are comparable to results obtained in humans treated with PD. Effluent dialysate can be drained repeatedly to measure\nconcentration of various bioactive molecules and to correlate the results with the peritoneal permeability. Additionally we can study\nin in vitro conditions properties of the effluent dialysate on cultured peritoneal mesothelial cells or fibroblasts.We can evaluate acute\nand chronic effect of various additives to the dialysis fluid on function and permeability of the peritoneum. Results from such study\nare even more relevant to the clinical scenario when experiments are performed in uremic rats. Our experimental animal PD model\nnot only helps to understand the pathophysiology of PD but also can be used for testing biocompatibility of new PD fluids.
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